I managed to snag one of the bus only application 451s (the only ones with a titanium comp wheel)... I must say that I really like mine. But to be honest unless you find another 451VeTi (the Ti denotes the titanium wheel) there really isn't much advantage to the 451 over the 351.
The 351 can be machined/modified to be a direct fit to a T3 manifold <-12valve has done this check out his thread
HE351VE on a VP44 truck - Competition Diesel.Com - Bringing The BEST Together
The 351, as far as I can tell, also isn't as finicky about tuning the min and max housing size. It also has a smaller exhaust housing and smaller turbine wheel, both of which aid it in spooling up ridiculously fast (though that's not to say that the 451 is slow by any means).
There's my $.02
EDIT: FYI here are the average dimensions of the wheels in both;
451
Comp
IND 60mm
EXD 90mm
Turbine
IND 74mm (76mm for other than bus applications)
EXD 60mm
351
Comp
IND 60mm
EXD 88mm
Turbine
IND 70mm
EXD 60mm