The higher compression pistons can give you slightly better fuel economy with a little snappier throttle response. The lower compression are better for higher boost applications.
I'm in the process of rebuilding and will be putting in the HO pistons along with the new switch blade turbo and cam shaft. Porting does not help fuel economy. You want high velocity. The right cam can help fuel economy in two ways, it can lower the pumping losses and it can allow better filling of the cylinder with less HP loss. The right fuel injector will help fuel economy as well, as the injectors get larger, they advance the timing. For best economy you want to lower your pumping losses as low as possible and you want to lower your throttle input as low as possible. Then the rest just becomes drive line losses and drag.
I will be running at around 1600 RPMs and 2-3 lbs of boost at 65 mph. The cam will lower the torque curve to around 1400. When towing I will put it in tow haul and kick out OD so that my RPMs will be around 1900 at 60-65. Gotta love Allison.
MPG goal is around 26-28 on the highway and to get this I will probably have to change out the front wheel bearings with lock out hubs. (there's a guy who got 27 consistently with his truck with some of these mods.)
Now if you are going for power then some of these things overlap and at some point and fuel economy just goes out the window.