I have been running a 2 piece, it is a 4" with 1480 ujoints, and an upgraded carrier. I had a 1 piece, but had this idea that I might drag race a little also, of course I have never done any drag racing yet.
Nothing wrong with using a two piece if you beef it up a bit and the angle isn't to steep from a lift or something. My original truck was a two piece we upgraded to the 1480's and used HD International carrier bearing. I never broke a rear drive line. check your straps alot, through bolt if you have to, and don't use the greasable universal joints as there weaker.