I ran a set of drilled tubes for a while and then changed them back to stock tubes. Didn't see a bit of difference. IMO, it doesn't help a thing drilling them out. As mentioned, their filter can help but, that shouldn't be an issue if your fuel is well filtered already.
As for the rail.... I have to disagree with you guys about it's benefit. There may be no hp benefit but, it definitely helps dampen the high psi pulses from the CP3 because of having a larger "tank", which in turn can only benefit your injectors.