I have tried a lot of combinations with the Redline (and other fueling boxes). There isn't a clear winner. Each has it's advantages and disadvantages. My current favorite is the Redline box with the Smarty Revo.
The type R powerpuck makes the most hp.
The drag comp allows the most adjust-ability. Doug (JetPilot) is right about that. When the pump wire is not attached, both the main and sub levels still change the CAN buss fueling. The sub levels make the changes based more on boost, and the main levels more on rpm and throttle position. With drag racing this allows a lot of options as far as getting the truck to hook up and to spool quickly and cleanly off the line. It's also dead nuts consistent.
The Adrenaline is not very consistent, and is hard to build and hold a steady boost when staging.
The Smarty is very consistent, easy to build and hold boost, and seems to having better timing maps. At least on my truck. My 02 is one of those that when the weather is cold, suffers from to much timing on the top end. This really shows up with the Drag Comp. With the Smarty it never has the problem. With the Smarty power levels I can change how the fuel is delivered, and with the Revo software I can adjust the timing, fuel duration, and torque management (how sensitive the pedal is).
Remember this is on my truck, other trucks may respond differently. Also, my main usage, besides daily driving, is drag racing. If your main interests are sled pulling or dyno testing, then your results maybe different.
Paul