Sounding like grounds, or a schizophrenic ECM.
I'd lean towards ecm is going loony.
Mark.
^^^^
Check ALL and I mean ALL your battery cables. Make sure they are clean. Check the grounds to the engine and body too.
Make sure your batteries are good as well.
I have had to on some trucks add ground leads before to get rid of little gremlins. Mostly on 06 trucks for one reason or another.
For your reference:
P2121-PPS CONFORMANCE ERROR
P2122-PPS 1 VOLTAGE TOO LOW
P2127-PPS 2 VOLTAGE TOO LOW
The plug pinout for your truck at the pedal is:
CAV-- CIRCUIT--------- FUNCTION
1----- F856 20YL/PK----- 5 VOLT SUPPLY
2----- K29 20WT/BR----- APPS NO. 2 SIGNAL
3----- K400 20BR/VT----- APPS NO. 2 RETURN
4----- K167 20BR/YL----- APPS NO. 1 RETURN
5----- K23 20BR/WT------ APPS NO. 1 SIGNAL
6----- F855 20PK/YL------ 5 VOLT SUPPLY
As Mark stated. I bet your 5v ref signal is low/bad, or dropping out. Check out the wiring from the ECM to the pedal making sure your harness is intact and check resistance for corrosion. If not than the ECM may be the culprit.