I think that a bigger secondary is more efficient for a given primary, and should therefore make more power.
Why? First, a bigger secondary poses less restriction to the flow from the primary. Second, that bigger secondary's turbine will swallow more gasflow, reducing the amount of gas that has to be wastegated around it.
When you hit the spray, you're going to want as much turbine area as you can get on BOTH turbos. That means larger A/R housings than you'd care for on the street to fight lag. That's what you give up to make the big power numbers.
Larger turbos might be overkill for a given HP level, but where they operate on their map will have a huge effect on drive pressure. This is where oversized (biggish) turbos can really pay off. If you have something that's right in the fat part of the middle island or close to it, your drive energy for a given HP can be cut way down.
If you're shooting for big HP on the spray, you gotta have a huge gate on top and/or a large, free-flowing turbine on top. Even the 74mm wheel of a Silver Bullet is too small for a big shot of nitrous. This is where something like a Garrett GT42 on top (82mm wheel) will free up some HP. Yes, it's laggy, but that's the the price for big nitrous HP.
Just like injectors can be optimized for spray or not (mach 8 vs 7), the turbos need to be optimized for the spray as well.
Justin