I ran a 351/S475 for years and while it's a great DD set up, the 351 can only handle so much - on the exhaust and comp side. You have a good amount of fuel also.
You're aware of the DP issues; I see you're monitoring that. But, the primary's air can get restricted (and hot) by the 351 comp. That contributes to the high EGT and you'll get high primary boost psi because the 351 can't move the volume the 488 pushes.
The answer is usually to drive the 351 harder. But, to do that you must keep the gate tighter/closed longer, and then you increase DP, EGTs...
Also consider that it's winter. What will summer temps do to EGTs?
Of course, check all the basics (leaks, AFC, timing, etc.) but in my opinion you'll have to make a choice. Either you can ease off slightly on the fuel (smaller injectors), or go to an S36X secondary.
For DD and towing, the smaller injectors would get you a snappy, torquey, clean-running truck in the 600hp range with acceptable EGT. Revs 3k max.
If you're a peak power guy and like to turn rpm, the S300 (like a 63/68) would be the way to go.
Good luck,
MQ