I used to own a 99' 24 valve, I drove it for several years with the stock HX35 and several more years with an He351.
Cruising boost is higher with the He351. Cool-down time at idle is longer with the He351. Initial boost 0-5 is faster with the He. Mid boost 5-15 psi seemed to come on quicker with the HX (we're talking split seconds here). Peak boost, top-end power came on quicker with the He. Seemed like once the He hit about 30 psi boost, it started to make more power than the HX. Top-end with the He351 with modded wastegate set to 42-48 psi had 50-60 more horsepower with the same fueling. My truck was pretty heavily overfueled with 150HP injectors and Quad Adrenaline, otherwise I don't think it would have picked up that much HP, maybe 20-40 on a normal truck.
I did like towing a little bit better with the He351, it wasn't leaps and bounds better, but it was better. Although the exhaust housing is smaller, it seemed to have lower egt's when towing up grades. I'd guess that's partially due to the larger compressor = more air flow into the motor combined with the larger exhaust outlet and full 4" exhaust vs the HX35 that necks down to 2.5" at the turbine housing exit.
As I recall, the tighter exhaust housing on the He351 did seem to hurt fuel economy about 0.5 mpg.
With all that said, if I were in your shoes and I could pick-up a hybrid Hx35 with 60mm compressor for the same price as a used He351, I would stick with the HX35. No sense in reworking the exhaust and charge air piping when you can get basically the same performance with a hybrid HX.