Well, I'm sure it depends on the size of your primary charger... My primary is a lot larger than the secondary... ATS's Aurora 5000 primary and HE351 secondary (stock) chargers... ATS setup has the primary opening the WG, and after putting gauges on the chargers I see why.. The HE351 secondary top turbo is working in its designed efficiency range of 30-40lbs. when the primary steps in relieves it of its duty..
The secondary is fully open @ 40lbs which is at it's max efficiency level (hotter gases) it spools the primary charger way faster than before when set to open @ lower settings.. I defiantly noticed much better pull through out the whole power band... When the WG was set to open sooner (24lbs.) I would notice a pause in the boost and power the moment the gate opened.
Total boost jumps right up to 40lbs. which is when the primary charger is opening the WG @ 29-30lbs...
You need to get a cheap PSI gauge from Lowes ($10) put a 1/4" tee on the WG hose run the gauge up to the windshield.. Set your WG to open close to its rated max efficiency, letting your primary charger open the WG... With the gauge on the primary charger and you know what psi you set the WG to open, you can watch your boost gauge and see what the boost levels are when the primary charger opens the gate and takes over for the secondary.
Now you can fine tune the WG to open depending on your chargers efficiency map ratings.. The key is knowing the efficiency of your top charger so as not to over work it..
Sorry for rambling