I would strongly encourage you to do the 3582 as the secondary. I have a 3782 over 4508 both GT models, and am comfortably (as far as air, smoke, and EGT are concerned) making about 900 to the wheels. Truck is an 06 with 165 nozzles. I tow a max of about 10,000 lbs. and do need to think a little about how I drive it as the turbos are somewhat big and lazy for that. I love it on the street, just playing, and if you don't mind a quick shot of smoke during spoolup, it lights quick. What I mean by this is if you floor it hard with no boost, it lights pretty good. If it is already making 15- 20, it just burys the gauge instantly when you hit it. I have a 50mm ED external gate and 2nd gen manifold, but not a steed, PDI I think, 3 piece.
My opinion, the 3582 and 4202 combo would be perfect for you. It will spool quicker, make more boost cruising, and with an external gate (tuned properly) it will not have any back pressure issues at all. Also, no need for the T6 flange on the primary, mine has a 1.28 with a T4 foot, and I can only get above 1:1 above 70 lbs. of boost.
You won't believe how easy it is to make 600 hp with that truck. And it will pull the bend out of a river!! Good luck....