As others have stated, the GTX wheels are probably pointless for your application, being a compound setup. I would expect you to see 30-40 lbs of boost while climbing a grade loaded. I suggest looking at how the maps compare from gt to gtx at about a 2.5 pressure ratio. Probably negligible at best. I do, however, like the ball bearing primary as well, being the duration of time you will be holding an elevated boost number from it. Having the water cooled chra will certainly make it last longer, in my opinion.
I think a T4 manifold is not needed as my truck has zero drive pressure issues with a t3, and I would expect the secondary mounted to the manifold to respond quicker if you keep the velocity up and the heat moving into the turbine wheel. I agree, being on comp d, the typical mindset is to build it to grow as funds become available. However, if the OP keeps his word, a 600 hp limit, he will be happier with the truck if he keeps the turbos sized properly, and not just to please the onlookers.
Very interested how this turns out...