Without being able to log (and tell for sure), i can only tell you what i see in the post injection tables....
And from a stock tune perspective, i can say that i don't believe driving under most normal (non towing) operating conditions would shut off the post injection event other than normal acceleration from a stop.... It doesnt appear that it stays active (depending on the nature of the tune of course) above about 25% throttle - however at crusing / highway speeds i beleive post injection WOULD be active... So, in terms of an effect on mileage, i believe it could have a measurable impact on mileage. In terms of being the cause of melting pistons as someone else asked, i can't even speculate. I'm excited to start logging these trucks so the 'mystery' can be taken out of what they're actually doing.
In terms of noise, especially noise while cruising, i agree with Nick in that his truck seems much quieter (in terms of engine noise) to me...
So far i think there have been some big accomlishments on these trucks and what the 'normal' guy would hope to gain from his truck over what he's been able to have in the past...