Yes it effects load, because unless you are accelerating the hp demand is constant (relatively and for this arguments sake). So assuming it takes a 2000us pulse to get the hp (ignore rail pressure just for the sake of the argument). With stock tables lets say that is in the 35% load are, if you increase the duration then it still only takes 2000us but now 2000us may be in the 25% load. If you decrease duration you might now be pulling from the 50% load. Those are extremes to visualize the point.
So that's why it may have an effect, but I don't think much on the load where I was at looking at my calculations.
Injectors have the same effect as decreasing duration. Since you get more fuel with each injection the ECM goes to a lower load/duration to get the fuel needed. This is also why the overhead goes crazy high with big injectors, the ECM doesn't think hardly any fuel is being injected.
With a couple of very small exceptions the duration tables from 03-07 are the same, so with similar trucks, timing, mods, etc it's not surprising you are pulling from the same load cells. For me doing 72 is less than 20% load on flat cruise, around 15% with stock duration in all but about a dozen cells.